The synthesis of aspirin may be achieved in one simple step o-acetylation of salicylic acid (figure 1), which is incorporated into many undergraduate synthetic chemistry laboratory courses the purity of the product as a pharmaceutical is crucial, and objectives the aim of the experiment is to introduce nmr spectroscopy. Experiment 8 – synthesis of aspirin aspirin is an effective analgesic (pain reliever), antipyretic (fever reducer) and anti-inflammatory agent and is one of the most widely used non-prescription drugs the use of aspirin had its origin in the 18th century, when it was found that an extract from the bark of willow trees was useful. Objective: to determine the amount of aspirin in the whole of the given solution introduction: charles frederic gerhardt, a french chemist was the first to prepare aspirin in 1853 aspirin is also known as acetylsalicylic acid it is the acetyl derivative of salicylic acid and is an example of a salicylate drug iupac name:. The crude product of reaction (2) will not be pure, it will be purified by recrystallization from an ethanol- water solution during recrystallization , most of the impurities remain in solution while crystals of aspirin slowly form and separate from the liquid phase your textbook 1 p569 gives the following description of. Nowadays, salicylic acid is administered in the form of aspirin which is less irritating to the stomach than salicylic acid to prepare aspirin, salicylic acid is reacted with an excess of acetic anhydride a small amount of a strong acid is used as a catalyst which speeds up the reaction in this experiment, phosphoric acid will be. O explanation of whether the results support or refute the hypothesis o explanation of the overall suitability of the method to investigate the hypothesis ( this purpose of this experiment is to determine the mass of acetylsalicylic acid in a commercial aspirin tablet because drug manufacturing is overseen by the food and. Synthesis of acetylsalicylic acid by the german chemist felix hoffmann in 1893 your two primary objectives in this experiment will be to synthesize and analyze aspirin there is more than one way to synthesize aspirin in this experiment, you will react acetic anhydride with salicylic acid in the presence of phosphoric acid. Aspirin® is the trademark for ester - acetylsalicylic acid - which is a prescription- free drug, used in the therapy of painful, inflammatory and feverish states the active ingredient in aspirin also prevents infections and damage to blood vessels the efficiency of any drug depends on its chemical stability hydrolysis of the drug.
Acetylsalicylic acid 50-78-2 100 toxicological data on ingredients: acetylsalicylic acid: oral (ld50): acute: 200 mg/kg [rat] section 3: hazards below the exposure limit personal protection: splash goggles lab coat dust respirator be sure to use an approved/certified respirator or equivalent. In this experiment, this compound is synthesized using commercial aspirin tablets as the starting material once the excipients and additives of the tablets are eliminated, the remaining acetyl salicylic acid is converted into methyl salicylate by two simultaneous processes of transesterification–fischer-speier esterification. We will prepare aspirin by reacting salicylic acid 1 with an excess of acetic anhydride 2 to produce aspirin 3 and acetic acid 4 : o oh oh o o o o oh o o o oh h3po4 (cat) + + 1 2 3 4 the solid aspirin product will be separated from the reaction mixture by suction filtration and further purified by recrystallization. This study was conducted on the industrial production of acetylsalicylic acid as neither the reactants nor products are toxic or carcinogenic the reaction temperature and pressure can be easily reached in lab and the reaction is quick so that many experiments can be made in a short time furthermore the.
After completing this experiment, the student should be able to: 1 prepare standard solutions 2 construct calibration curve based on beer's law 3 use beer's law to determine molar absorptivity 4 explain the fundamental principal behind spectrophotometric analysis introduction acetyl salicylic acid (asa) is one of the. The aspirin screen experiment is an interactive resource which allows you to run your own experiment each of the four levels take approximately 30 minutes to complete and are designed to be used as pre-lab activities in class or as homework.
Download citation | experiments with asp | aspirin is much more than just a pain remedy aspirin is a compound that can be used to demonstrate many chemical principles in the high school classroom in this series of experiments, we demonstrate how aspirin can be synthesized and characterized. The average tablet contains about 325 milligrams of the active ingredient acetylsalicylic acid with an inert binding material such as starch aspirin is used to relieve in this laboratory exercise, you can prepare aspirin (acetylsalicylic acid) from salicylic acid and acetic anhydride using the following reaction.
Experiment overview in this experiment, students examine the hydrolysis of aspirin, acetylsalicylic acid, under different conditions the hydrolysis of aspirin occurs much more rapidly in basic conditions, a fact which is illustrative of an important principle in pharmacology that is, the stability of drugs and. Aspirin after it has been “prepped” with an iron solution to give it color objectives in this experiment, you will • synthesize a sample of acetylsalicylic acid (aspirin) • calculate the percent yield of your synthesis • measure the melting temperature of your aspirin sample • conduct a spectrophotometric analysis of your. Aspirin | hc9h7o4 or c9h8o4 | cid 2244 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more fda pharmacology summary from fda pharm classes aspirin is an orally administered non- steroidal.
The reaction that is used for the synthesis is shown below in this reaction, an excess of acetic anhydride (c4h6o3) is added to a measured mass of salicylic acid (c7h6o3) in the presence of a catalyst, sulfuric acid (h2so4) the mixture is heated to form the acetylsalicylic acid (c9h8o4) and acetic acid (c2h4o2) after the. Analgesics are compounds used to reduce pain, antipyretics are compounds used to reduce fever one popular drug that does both is aspirin. Free essay: monica perez experiment 8: acetylsalicylic acid experiment 01/25/ 2013 chm lab- 2211 sec 0016 instructor: jennifer reed introduction: commonly.